The seismic probabilistic risk assessment is an important methodology to evaluate the seismic safety of nuclear power plants. In this assessment, the core damage frequency is evaluated from the seismic hazard, seismic fragilities, and accident sequence. Regarding the seismic fragility evaluation, the probabilistic fracture mechanics can be applied as a useful evaluation technique for aged piping systems with crack or wall thinning due to the age-related degradation mechanisms. In this study, to advance seismic probabilistic risk assessment methodology of nuclear power plants that have been in operation for a long time, a guideline on the seismic fragility evaluation of the typical aged piping systems of nuclear power plants has been developed considering the age-related degradation mechanisms. This paper provides an outline of the guideline and several examples of seismic fragility evaluation based on the guideline and utilizing the probabilistic fracture mechanics analysis code.