Preventing catastrophic failure of engineering components is critical during the exploration and production of oil and gas resources from the offshore deep-water fields in Brazil. Pre-salt reserves are associated with high concentration of aggregated elements to hydrocarbons, particularly carbon dioxide (CO2) and hydrogen sulfide (H2S) which, in the presence of water can produce highly corrosive elements. One solution to this problem is to apply a metal liner made of corrosion-resistant alloy (CRA) internally to the carbon steel pipe. Such a bi-metallic configuration, commonly referred to as a lined pipe or clad pipe, consists essentially of a relatively thin CRA material pipe physically or metallurgically joined to the main carbon steel outer pipe. This experimental study presents an investigation of the ductile tearing properties for the girth weld of a typical C-Mn pipe internally clad with Inconel 625 CRA alloy using experimentally measured crack growth resistance curves. Here, the material of the external pipe is an API 5L Grade X65 pipeline steel and the inner clad layer is made of Inconel nickel-chromium alloy 625 (UNS N06625). The higher mechanical strength and superior resistance to a wide range of corrosive environments of unusual severity for this material derived from the combination of the nickel-chromium matrix with other microalloying elements. Testing of the pipeline girth welds employed clamped SE(T) specimens with a weld centerline notch to determine the crack growth resistance curves based upon the unloading compliance (UC) method using a single specimen method and the multi-specimen technique. The SE(T) specimens were extracted from a clad pipe having an external diameter of 220 mm and thickness of 23 mm. Further, the current experimental characterization provides toughness data that serve to evaluate the effectiveness of current procedures in determining accurate experimentally measured R-curves for this class of material.