High density polyethylene (HDPE) is widely used in city water and gas piping system and even in nuclear engineering for its excellent properties in flexibility, impact resistance, aging and corrosion resistance, reliable connection, long service life. It is generally believed that the typical failure mode of PE pipe under long-term static pressure load is the slow crack growth (SCG) caused by creep crack initiation (CCI) and creep crack growth (CCG), which is a kind of quasi-brittle failure. Scratching often occurs during PE pipe installation due to the drag of pipe without any protection, which would leave axial cracks as the initial defect. This would harm the long term performance of pressurized HDPE pipe. In the present work, the creep crack kinetics was experimentally determined in term of C* integral, and then CCG behavior of PE pipe with axial semi-elliptical crack was discussed. With the help of a CARE electronic universal testing machine and DIC displacement measuring system, creep tests are performed with smooth bar specimen of PE100 pipe parent material. And the stationary creep law parameters were determined. The crack opening displacement (COD) rates were determined by creep cracking test with cracked round bar specimen. With the help of compliance calibration tests, the COD curves were changed into crack propagation curves and the creep crack kinetics was eventually determined in term of C* integral. By assuming an semi-elliptical crack front with nearly the same C* integral, the creep crack propagation was predicted with the determined crack kinetics. And the allowable initial crack size was also determined for the PE pipe discussed. Compared with that determined in terms of SIF, current study yields much margin for the allowable initial crack.