Pile foundation settlement might cause a disastrous consequence to an in-service pressure pipeline. Flaws, which are unavoidable in the pipeline, lead to reduction of load-supporting capability and service life of the pipeline. So fracture failure risk analysis of in-service pressure pipeline is important in engineering. Failure probability of pipeline due to pile foundation settlement is computed by using the well-known safety assessment procedure R6. Three-moment equation is adopted to compute bending moment in the condition of n piles, where n is the number of piles. A numerical example was presented to illustrate the application of fracture failure risk analysis to determine the failure probability of the pressure pipeline, considering the uncertainties in various internal operating loadings and external forces, flaw sizes, material fracture toughness and flow stress. Furthermore, the failure probabilities of each defect and the whole pipeline were obtained.

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