We address the design and analysis of blast resistant panels consisting of layered substructures with fluid filled chambers. The panels are designed to absorb energy from an air blast by progressive elastic-plastic, through-thickness collapse of the panel substructure. This mechanism of energy absorption is enhanced further by the presence of fluid within alternating chambers of the panel substructure. The fluid primarily contributes to blast effects mitigation by providing increased initial mass to the resisting system, by direct dissipation of energy through viscosity, and by redirecting momentum imparted to the system. Analyses are presented first of the structural system design without fluid. Plastic collapse mechanisms are addressed for optimum design for quasi-static loading. Analytical, numerical and experimental results are discussed. Selected panel geometry is then used to analyze the system with fluid encasement. Simulations of fluid-structure interaction during panel collapse due to adjacent air blasts are presented. The key aspects of optimal design for blast effects mitigation are discussed. The importance of maximizing fluid momentum transfer and redirection, the encasement details including structural passages for prescribed fluid flow, and the system viscosity resulting from fluid-structure dynamics are examined.

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