This paper presents a parametric design study of the mooring system for a floating offshore wind turbine. We selected the OC4 DeepCwind semisubmersible floating wind turbine as the reference structure. The design water depth was 50 m, which was the transition area between the shallow and deep waters. For the floating wind turbine working in this water area, the restoring forces and moments provided by the mooring lines were significantly affected by the heave motion amplitude of the platform. Thus, the mooring design for the wind turbine in this working depth was different from the deep-water catenary mooring system. In this study, the chosen design parameters were declination angle, fairlead position, mooring line length, environmental load direction, and mooring line number. We conducted fully coupled aero-hydro dynamic simulations of the floating wind turbine system in the time domain to investigate the influences of different mooring configurations on the platform motion and the mooring tension. We evaluated both survival and accidental conditions to analyze the mooring safety under typhoon and mooring fail conditions. On the basis of the simulation results, this study made several design recommendations for the mooring configuration for floating wind turbines in intermediate water depth applied in China.