The process of offshore drilling faces several challenges. The process of mixing of water and oil results in issues that lead to the contamination of ocean water. Therefore, this study focuses on the hazards and the measures taken to cover up those hazards of offshore drilling. There are types of offshore drilling hazards such as health hazards and safety hazards. In connection to identify the hazards facing in offshore drilling and taking measures to prevent these hazards, ISM (interpretive structural modeling) technique is used. Data is collected through extensive literature review and by conducting interviews from Japan and China. Experts from academia and industry specialists are approached for interview. Eight important Measures to prevent the hazards due to offshore drilling have been identified. And the relationship among these measures are depicted by constructing SSIM (structural self-interaction matrix). The next step of ISM technique which is reachability matrix, developed which also establish the driving and dependence power of each variable. After reachability matrix a diagram is discussed where the measures are depicted in relation to their dependency, drive and independency levels, which show the influence of each measure with other. This study is valuable in the field of offshore drilling for top managers in decision making and for literature review study. Further, this study has some limitation, if the contributions of experts from other countries would have been exerted in our research that may came up with more measures for the prevention of hazards encounter in Offshore oil drilling. Further, quantitative analysis should be considered to find the absolute values to evaluate the measure.