Recent advances in nanoscience offer great promise for the nanomedicine sector. These advances in the nanotechnology field will undoubtedly increase both human and environmental exposures to engineered nanomaterials. Whether these exposures pose a significant risk remains uncertain. Despite recent collective progress there remain gaps in our understanding of the nanomaterials physiochemical properties that drive or dictate biological compatibility. The development and implementation of rapid relevant and efficient testing strategies to assess these emerging materials prior to large-scale exposures could help advance this exciting field. I will present a powerful approach that utilizes a dynamic in vivo zebrafish embryonic assay to rapidly define the biological responses to nanomaterial exposures. Early developmental life stages are often uniquely sensitive to environmental insults, due in part to the enormous changes in cellular differentiation, proliferation and migration required to form the required cell types, tissues and organs. Molecular signaling underlies all of these processes. Most toxic responses result from disruption of proper molecular signaling, thus, early developmental life stages are perhaps the ideal life stage to determine if nanomaterials perturb normal biological pathways. Through automation and rapid throughput approaches, a systematic and iterative strategy has been deployed to help elucidate the nanomaterials properties that drive biological responses.
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ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology
February 4–6, 2013
Boston, Massachusetts, USA
Conference Sponsors:
- Nanotechnology Institute
- Bioengineering Division
ISBN:
978-0-7918-4533-2
PROCEEDINGS PAPER
Rapid In Vivo Assessment of the Nano/Bio Interface Available to Purchase
Robert L. Tanguay,
Robert L. Tanguay
Oregon State University, Corvallis, OR
Oregon Nanoscience and Microtechnologies Institute, Corvallis, OR
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Lisa Truong,
Lisa Truong
Oregon State University, Corvallis, OR
Oregon Nanoscience and Microtechnologies Institute, Corvallis, OR
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Tatiana Zaikova,
Tatiana Zaikova
University of Oregon, Eugene, OR
Oregon Nanoscience and Microtechnologies Institute, Corvallis, OR
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James E. Hutchison
James E. Hutchison
University of Oregon, Eugene, OR
Oregon Nanoscience and Microtechnologies Institute, Corvallis, OR
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Robert L. Tanguay
Oregon State University, Corvallis, OR
Oregon Nanoscience and Microtechnologies Institute, Corvallis, OR
Lisa Truong
Oregon State University, Corvallis, OR
Oregon Nanoscience and Microtechnologies Institute, Corvallis, OR
Tatiana Zaikova
University of Oregon, Eugene, OR
Oregon Nanoscience and Microtechnologies Institute, Corvallis, OR
James E. Hutchison
University of Oregon, Eugene, OR
Oregon Nanoscience and Microtechnologies Institute, Corvallis, OR
Paper No:
NEMB2013-93153, V001T08A001; 3 pages
Published Online:
November 4, 2013
Citation
Tanguay, RL, Truong, L, Zaikova, T, & Hutchison, JE. "Rapid In Vivo Assessment of the Nano/Bio Interface." Proceedings of the ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology. ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology. Boston, Massachusetts, USA. February 4–6, 2013. V001T08A001. ASME. https://doi.org/10.1115/NEMB2013-93153
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