Triple-negative breast cancer (TNBC) accounts for ∼25% of breast cancer among premenopausal African-American and Latino women1. Curcumin (diferuloylmethane; CCM), a natural polyphenol extracted from turmeric, has chemopreventive and chemotherapeutic activity in various cancers 2,3 and inhibits growth and invasion of TNBC/basal-like MDA-MB-231 human breast cancer cells 4. CCM has been reported to affect all stages of tumor progression and metastases due to its interactions with multiple targets. We employ a novel approach utilizing both computational and experimental modeling to characterize and analyze TNBC and the 3D tumor microenvironment responses to albumin bound CCM particles (ACP) versus CCM alone.
- Nanotechnology Institute
- Bioengineering Division
An Innovative Approach for Curcumin Delivery for Breast Cancer Using Albumin Nanoparticles
Soucy, P, Ehringer, W, Klinge, C, Frieboes, H, & Gobin, A. "An Innovative Approach for Curcumin Delivery for Breast Cancer Using Albumin Nanoparticles." Proceedings of the ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology. ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology. Boston, Massachusetts, USA. February 4–6, 2013. V001T07A005. ASME. https://doi.org/10.1115/NEMB2013-93295
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