Multiple formulations of nano-sized particles, capsules, dendrimers, lipids, ceramics and genetic materials are being investigated in multiple labs for delivery of therapeutic moieties to targeted tissues. Interest is driven by reducing health care costs while increasing therapeutic efficacy and cost of treatment. One technology, magnetic targeting, incorporates iron oxide nanoparticles, to target nanomedicine payloads, down the gradients of external magnetic fields. When iron oxide crystal domains are less than ∼20–40 nm, particles become superparamagnetic (SPION), that is exhibit no remanent induction but very high magnetic susceptibility in the presence of an external magnetic field. Thus, targeting can be vectored by magnetic lines of flux. Particles can be pulled out of the microcirculation and across membranes into tissues. Two target organs that can employ magnetic targeting are the heart (epicardium) and inner ear (cochlea).
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ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
February 7–10, 2010
Houston, Texas, USA
Conference Sponsors:
- ASME Nanotechnology Council
ISBN:
978-0-7918-4392-5
PROCEEDINGS PAPER
Magnetic Targeting of Therapeutics
Kenneth Dormer,
Kenneth Dormer
University of Oklahoma HSC, Oklahoma City, OK
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Sunny Po,
Sunny Po
University of Oklahoma HSC, Oklahoma City, OK
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Kejian Chen,
Kejian Chen
Hough Ear Institute, Oklahoma City, OK
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Benjamin Scherlag,
Benjamin Scherlag
University of Oklahoma HSC, Oklahoma City, OK
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Isaac Rutel,
Isaac Rutel
University of Oklahoma HSC, Oklahoma City, OK
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Kytai Nguyen,
Kytai Nguyen
University of Texas - Arlington, Arlington, TX
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Satish Kyriyavar,
Satish Kyriyavar
Hough Ear Institute, Oklahoma City, OK
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Brian Grady,
Brian Grady
University of Oklahoma, Norman, OK
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Benjamin Shapiro,
Benjamin Shapiro
University of Maryland, College Park, MD
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Xinsheng Gao,
Xinsheng Gao
Hough Ear Institute, Oklahoma City, OK
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Xiaoping Du,
Xiaoping Du
Hough Ear Institute, Oklahoma City, OK
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David Bourne,
David Bourne
University of Oklahoma HSC, Oklahoma City, OK
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Kar-Ming Fung,
Kar-Ming Fung
University of Oklahoma HSC, Oklahoma City, OK
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Richard Kopke
Richard Kopke
Hough Ear Institute, Oklahoma City, OK
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Kenneth Dormer
University of Oklahoma HSC, Oklahoma City, OK
Sunny Po
University of Oklahoma HSC, Oklahoma City, OK
Kejian Chen
Hough Ear Institute, Oklahoma City, OK
Benjamin Scherlag
University of Oklahoma HSC, Oklahoma City, OK
Isaac Rutel
University of Oklahoma HSC, Oklahoma City, OK
Kytai Nguyen
University of Texas - Arlington, Arlington, TX
Satish Kyriyavar
Hough Ear Institute, Oklahoma City, OK
Brian Grady
University of Oklahoma, Norman, OK
Benjamin Shapiro
University of Maryland, College Park, MD
Xinsheng Gao
Hough Ear Institute, Oklahoma City, OK
Xiaoping Du
Hough Ear Institute, Oklahoma City, OK
David Bourne
University of Oklahoma HSC, Oklahoma City, OK
Kar-Ming Fung
University of Oklahoma HSC, Oklahoma City, OK
Richard Kopke
Hough Ear Institute, Oklahoma City, OK
Paper No:
NEMB2010-13022, pp. 85-86; 2 pages
Published Online:
December 22, 2010
Citation
Dormer, K, Po, S, Chen, K, Scherlag, B, Rutel, I, Nguyen, K, Kyriyavar, S, Grady, B, Shapiro, B, Gao, X, Du, X, Bourne, D, Fung, K, & Kopke, R. "Magnetic Targeting of Therapeutics." Proceedings of the ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. Houston, Texas, USA. February 7–10, 2010. pp. 85-86. ASME. https://doi.org/10.1115/NEMB2010-13022
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