We present a new biomechanical approach to measure nanoscale platelet contractile forces, which play an important role in the regulation of hemostasis and thrombosis. Previous studies have indicated that platelets generate contractile forces through actin-myosin interactions that lead to clot retraction and stability. If platelets are unable to generate forces, then the clots they form are loosely-bound and may detach to cause an embolism. Likewise, a higher propensity toward contractility by platelets may cause excessive clot formation in arteries and block blood flow.
- ASME Nanotechnology Council
Platelet Nano-Forces are Similar on Fibronectin and Fibrinogen Ligands
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Liang, XM, & Sniadecki, NJ. "Platelet Nano-Forces are Similar on Fibronectin and Fibrinogen Ligands." Proceedings of the ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. Houston, Texas, USA. February 7–10, 2010. pp. 55-56. ASME. https://doi.org/10.1115/NEMB2010-13278
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