Congenital heart disease (CHD) affects about 1% of newborn babies in the US, and is the leading cause of non-infectious death in children. Abnormal blood flow dynamics during early development can lead to CHD. Although the effect of hemodynamic conditions on cardiac development — even under normal conditions — has been widely accepted, the mechanisms by which blood flow influences cardiac cell responses are only starting to emerge. Mathematical models of cardiac growth could then help elucidate key aspects of cardiac development.

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