Simulation of the Diffusion of Doxorubicin (DOX) in Polymer Pores for a Multiscale Nanodiamond Based Drug Delivery System Available to Purchase

A drug delivery system utilizing nanodiamonds has been proposed for the controlled release of the chemotherapeutic doxorubicin (DOX) [1,2]. The drug delivery system consists of a patch which is envisioned to be implanted immediately after a tumor removal surgery to target residual cancerous cells such that tumor reoccurrence can be effectively prevented. Therefore, long release times are desired for the patch to prevent any new cancerous tissue from forming. The patch is to be assembled in three different layers beginning with a bottom layer comprised of nonporous parylene. A layer of DOX loaded nanodimonds is deposited onto the base layer. Then a porous layer of parylene is accumulated on top of the nanodimonds. Nanodimonds are utilized because their release rates are based on pH, which changes near cancerous cells. Due to the complexity of the drug delivery system, models are created at several different scales.