Hydroxyapatite (HA) is known to promote osteogenicity and enhance mechanical strength of biopolymers. However, incorporating a large amount of HA into aporous biopolymer still remains a challenge. In this study, a new method was investigated to incorporate high HA loading into interconnected microporous poly(glycolic-co-lactic acid) (PLGA). Specifically, a tertiary blend comprising PLGA/PS/HA (40/40/20 wt%), prepared by melt blending under conditions for formation of a co-continuous structure, was annealed under small-strain oscillation between parallel plates. The results from different characterizations suggested that the applied small-strain oscillation substantially accelerated the migration of HA nanoparticles during annealing from the PS phase to the PLGA phase; nearly all HA particles were uniformly presented in the PLGA phase after a short period of annealing. After dissolution of the PS phase, a PLGA material with interconnected microporous structure was successfully produced, with a high HA loading above 30 wt%.
- ASME Nanotechnology Council
Preparation of Interconnected Microporous Poly(glycolic-co-lactic acid) With High Hydroxyapatite Loading
- Views Icon Views
- Share Icon Share
- Search Site
Zhang, W, Yao, D, Zhang, Q, Zhou, JG, & Lelkes, PI. "Preparation of Interconnected Microporous Poly(glycolic-co-lactic acid) With High Hydroxyapatite Loading." Proceedings of the ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. Houston, Texas, USA. February 7–10, 2010. pp. 199-202. ASME. https://doi.org/10.1115/NEMB2010-13119
Download citation file: