Hydroxyapatite (HA) is known to promote osteogenicity and enhance mechanical strength of biopolymers. However, incorporating a large amount of HA into aporous biopolymer still remains a challenge. In this study, a new method was investigated to incorporate high HA loading into interconnected microporous poly(glycolic-co-lactic acid) (PLGA). Specifically, a tertiary blend comprising PLGA/PS/HA (40/40/20 wt%), prepared by melt blending under conditions for formation of a co-continuous structure, was annealed under small-strain oscillation between parallel plates. The results from different characterizations suggested that the applied small-strain oscillation substantially accelerated the migration of HA nanoparticles during annealing from the PS phase to the PLGA phase; nearly all HA particles were uniformly presented in the PLGA phase after a short period of annealing. After dissolution of the PS phase, a PLGA material with interconnected microporous structure was successfully produced, with a high HA loading above 30 wt%.
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ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
February 7–10, 2010
Houston, Texas, USA
Conference Sponsors:
- ASME Nanotechnology Council
ISBN:
978-0-7918-4392-5
PROCEEDINGS PAPER
Preparation of Interconnected Microporous Poly(glycolic-co-lactic acid) With High Hydroxyapatite Loading
Wei Zhang,
Wei Zhang
Georgia Institute of Technology, Atlanta, GA
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Donggang Yao,
Donggang Yao
Georgia Institute of Technology, Atlanta, GA
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Qingwei Zhang,
Qingwei Zhang
Drexel University, Philadelphia, PA
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Jack G. Zhou,
Jack G. Zhou
Drexel University, Philadelphia, PA
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Peter I. Lelkes
Peter I. Lelkes
Drexel University, Philadelphia, PA
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Wei Zhang
Georgia Institute of Technology, Atlanta, GA
Donggang Yao
Georgia Institute of Technology, Atlanta, GA
Qingwei Zhang
Drexel University, Philadelphia, PA
Jack G. Zhou
Drexel University, Philadelphia, PA
Peter I. Lelkes
Drexel University, Philadelphia, PA
Paper No:
NEMB2010-13119, pp. 199-202; 4 pages
Published Online:
December 22, 2010
Citation
Zhang, W, Yao, D, Zhang, Q, Zhou, JG, & Lelkes, PI. "Preparation of Interconnected Microporous Poly(glycolic-co-lactic acid) With High Hydroxyapatite Loading." Proceedings of the ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. Houston, Texas, USA. February 7–10, 2010. pp. 199-202. ASME. https://doi.org/10.1115/NEMB2010-13119
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