A fast, accurate differential diagnosis is a tremendous challenge in clinical medicine. For example, in emergency settings differential diagnosis of infection from inflammation is needed, as a timely and actionable diagnosis is critical. Consequently, diagnostics capable of measuring multiple biomarkers would support clinical decision-making related to diagnosis, containment, and treatment. Microfluidic assays are exceptionally well-suited for near-patient clinical diagnostics (i.e., ambulance, emergency room, field hospital). We present spectrally multiplexed homogeneous electrophoretic immunoassays for specific protein disease biomarkers. Biomarkers are resolved quickly (< 60 s), in ultra-short separation lengths (< 1 mm), and at clinically relevant concentrations (nM). On-going work will be presented and centers on endogenous protein measurements in clinical samples in support of near-patient assessment.

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