Cell adhesion plays a fundamental role in numerous physiological and pathological processes, and measurements of the adhesion strength are important in fields ranging from basic cell biology research to the development of implantable biomaterials. Our group and others have recently demonstrated that microfluidic devices offer advantages for characterizing the adhesion of cells to protein-coated surfaces [1,2]. Microfluidic devices offer many advantages over conventional assays, including the ability to apply high shear stresses in the laminar regime and the opportunity to directly observe cell behavior during testing. However, a key disadvantage is that such assays require cells to be cultured inside closed microchannels. Assays based on closed channels restrict the types of surfaces that can be examined and are not compatible with many standard techniques in cell biology research. Furthermore, while techniques for cell culture in microchannels have become common, maintaining the viability of certain types of cells in channels remains a challenge.
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ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
February 7–10, 2010
Houston, Texas, USA
Conference Sponsors:
- ASME Nanotechnology Council
ISBN:
978-0-7918-4392-5
PROCEEDINGS PAPER
Hydrodynamically-Confined Microflows for Cell Adhesion Strength Measurement Available to Purchase
Kevin V. Christ,
Kevin V. Christ
University of Wisconsin at Madison, Madison, WI
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Kevin T. Turner
Kevin T. Turner
University of Wisconsin at Madison, Madison, WI
Search for other works by this author on:
Kevin V. Christ
University of Wisconsin at Madison, Madison, WI
Kevin T. Turner
University of Wisconsin at Madison, Madison, WI
Paper No:
NEMB2010-13007, pp. 113-114; 2 pages
Published Online:
December 22, 2010
Citation
Christ, KV, & Turner, KT. "Hydrodynamically-Confined Microflows for Cell Adhesion Strength Measurement." Proceedings of the ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. Houston, Texas, USA. February 7–10, 2010. pp. 113-114. ASME. https://doi.org/10.1115/NEMB2010-13007
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