A label-free technique capable of rapidly screening human blood samples simultaneously for multiple serum tumor markers would enable accurate and cost-effective diagnosis of cancer before physiological symptoms appear. Recently, microfabricated, bimaterial cantilever sensors have been demonstrated to detect DNA hybridization and antigen-antibody binding at clinically relevant concentrations. Cantilever sensors deflect measurably under the surface stress resulting when biomolecules immobilized on one surface of the sensor interact with their binding partners [1]. We present an array of cantilever sensors (silicon nitride with a gold coated surface) capable of simultaneously interrogating 100 different biomolecular interactions.
Volume Subject Area:
Devices and Systems
Topics:
Nanosensors,
Tumors,
Sensors,
Cantilevers,
Blood,
Cancer,
DNA,
Physiology,
Silicon nitride ceramics,
Stress
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Copyright © 2004
by ASME
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