A label-free technique capable of rapidly screening human blood samples simultaneously for multiple serum tumor markers would enable accurate and cost-effective diagnosis of cancer before physiological symptoms appear. Recently, microfabricated, bimaterial cantilever sensors have been demonstrated to detect DNA hybridization and antigen-antibody binding at clinically relevant concentrations. Cantilever sensors deflect measurably under the surface stress resulting when biomolecules immobilized on one surface of the sensor interact with their binding partners . We present an array of cantilever sensors (silicon nitride with a gold coated surface) capable of simultaneously interrogating 100 different biomolecular interactions.
Nanomechanical Sensor Array for Detection of Biomolecular Bindings: Toward a Label-Free Clinical Assay for Serum Tumor Markers
Yue, M, Stachowiak, JC, Lin, H, Castelino, K, Datar, R, Hansen, K, Thundat, T, Chakraborty, A, Cote, RJ, & Majumdar, A. "Nanomechanical Sensor Array for Detection of Biomolecular Bindings: Toward a Label-Free Clinical Assay for Serum Tumor Markers." Proceedings of the ASME 2004 3rd Integrated Nanosystems Conference. Design, Synthesis, and Applications. Pasadena, California, USA. September 22–24, 2004. pp. 27-28. ASME. https://doi.org/10.1115/NANO2004-46034
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