This paper presents an experimental study of modulation-assisted turning of Ti6Al4V. A piezo-actuated turning tool post has been designed and implemented on a CNC toolroom lathe to enable modulation-assisted turning process. Displacement and force measurements were performed to characterize the modulation turning process. Tool wear tests on conventional turning and modulation-assisted turning of Ti6Al4V with uncoated carbide tools were conducted for three different lubrication conditions, including dry, minimum quantity lubrication (MQL), and nano-platelet enhanced MQL (n-MQL). The tool wear study shows that modulation-assisted turning can reduce crater wear but increase the flank wear of the uncoated carbide tool. The cause leading to different performances of modulation-assisted turning on tool wear is discussed.