Post-surgery infection is one of the major causes of orthopedic implantation failure. Silver has been widely used as a broad-spectrum antimicrobial component in medical instrument. This paper presents a pioneering study on laser engineered net shaping (LENS) of titanium-silver (Ti-Ag) alloy for implant-related infection control. Ti-Ag alloy coupons were 3D printed through LENS process and characterized by 3D microscopy. The biofilm resistance and biocompatibility of the alloy samples were investigated. Results showed that the alloy significantly reduced the bacterial attachment for both Gram-positive and Gram-negative strains, and has no cytotoxicity to human fibroblast cells. This study demonstrated a great potential of laser 3D printed Ti-Ag alloy for orthopedic implant.

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