Microfluidic lab-on-a-chip (MLOC) technology is a promising approach for point-of-care (POC) diagnosis; low reagent consumption, high sensitivity and quick analysis time are the most prominent benefits. However, microfabrication of MLOCs utilizes specialized techniques and infrastructure, making conventional fabrication time consuming and difficult. While relatively inexpensive production techniques exist for POC diagnoses, such as replication of polymer-based (e.g., PDMS) microfluidic POC devices on lithographic molds, this approach has limitations including: further hydrophilic surface modifications of PDMS, inability to change lithographic mold Z dimensions, and slow prototyping. In contrast, stereo-lithographical (SLA) printing can integrate all of the necessary fabrication resources in one instrument, allowing highly versatile microfluidic devices to be made at low cost. In this paper, we report two microfabrication approaches of microfluidics utilizing (SLA) 3D printing technology: I) Direct SLA printing of channels and structures of a monolithic microfluidic POC device; II) Indirect fabrication, utilizing SLA 3D printed molds for PDMS based microfluidic device replication. Additionally, we discuss previous work providing a proof of concept of applications in POC diagnosis, using direct 3D printing fabrication (approach I). The robustness and simplicity of these protocols allow integrating 3D design and microfabrication with smartphone-based disease diagnosis as a stand-alone system, offering strong adaptability for establishing diagnostic capacity in resource-limited areas and low-income countries.
Skip Nav Destination
ASME 2017 12th International Manufacturing Science and Engineering Conference collocated with the JSME/ASME 2017 6th International Conference on Materials and Processing
June 4–8, 2017
Los Angeles, California, USA
Conference Sponsors:
- Manufacturing Engineering Division
ISBN:
978-0-7918-5075-6
PROCEEDINGS PAPER
3D Printing of Microfluidics for Point of Care Diagnosis Available to Purchase
John P. Sibbitt,
John P. Sibbitt
Kansas State University, Manhattan, KS
Search for other works by this author on:
Mei He
Mei He
Kansas State University, Manhattan, KS
Search for other works by this author on:
John P. Sibbitt
Kansas State University, Manhattan, KS
Mei He
Kansas State University, Manhattan, KS
Paper No:
MSEC2017-2778, V004T05A002; 8 pages
Published Online:
July 24, 2017
Citation
Sibbitt, JP, & He, M. "3D Printing of Microfluidics for Point of Care Diagnosis." Proceedings of the ASME 2017 12th International Manufacturing Science and Engineering Conference collocated with the JSME/ASME 2017 6th International Conference on Materials and Processing. Volume 4: Bio and Sustainable Manufacturing. Los Angeles, California, USA. June 4–8, 2017. V004T05A002. ASME. https://doi.org/10.1115/MSEC2017-2778
Download citation file:
48
Views
Related Proceedings Papers
Related Articles
A Microfluidic Device to Establish Concentration Gradients Using Reagent Density Differences
J Biomech Eng (December,2010)
Sacrificial Powder Pressure Control for Infiltration of Microscale Binder Jet Printed Metal Parts
J. Manuf. Sci. Eng (May,2024)
Process Robustness of Hot Embossing Microfluidic Devices
J. Manuf. Sci. Eng (June,2010)
Related Chapters
LC-MS/MS on Microfluidic Device for Chloramphenicol Determination in Milk and Honey Samples Based on Molecular Imprinted Polymers
International Conference on Computer and Electrical Engineering 4th (ICCEE 2011)
Getting Ready for Production
Total Quality Development: A Step by Step Guide to World Class Concurrent Engineering
Testing the Drift Reduction Potential of Some Adjuvants from Renewable Sources for Aerial Pesticide Applications
Pesticide Formulation and Delivery Systems: 43rd Volume, Creating Certainty in an Uncertain World