Poly(L-lactic acid) (PLLA) has been shown to have potential medical usage such as in drug delivery because it can degrade into bioabsorbable products in physiological environments, and its degradation is affected by crystallinity. In this paper, the effect of film formation method and annealing on the crystallinity of PLLA are investigated. The films are made through solvent casting and spin coating methods, and subsequent annealing is conducted. The resulting crystalline morphology, structure, conformation, and intermolecular interaction are examined using optical microscopy, X-ray diffraction, and Fourier transform infrared spectroscopy. It is observed that solvent casting produces category 1 spherulites while annealed spin coated films leads to spherulites of category 2. Distinct lamellar structures and intermolecular interactions in the two kinds of films have been shown. The results enable better understanding of the crystallinity in PLLA, which is essential for its drug delivery application.
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ASME 2011 International Manufacturing Science and Engineering Conference
June 13–17, 2011
Corvallis, Oregon, USA
Conference Sponsors:
- Manufacturing Engineering Division
ISBN:
978-0-7918-4430-4
PROCEEDINGS PAPER
Effect of Film Formation Method and Annealing on Crystallinity of Poly(L-Lactic Acid) Films Available to Purchase
Shan-Ting Hsu,
Shan-Ting Hsu
Columbia University, New York, NY
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Y. Lawrence Yao
Y. Lawrence Yao
Columbia University, New York, NY
Search for other works by this author on:
Shan-Ting Hsu
Columbia University, New York, NY
Y. Lawrence Yao
Columbia University, New York, NY
Paper No:
MSEC2011-50205, pp. 63-72; 10 pages
Published Online:
September 14, 2011
Citation
Hsu, S, & Yao, YL. "Effect of Film Formation Method and Annealing on Crystallinity of Poly(L-Lactic Acid) Films." Proceedings of the ASME 2011 International Manufacturing Science and Engineering Conference. ASME 2011 International Manufacturing Science and Engineering Conference, Volume 1. Corvallis, Oregon, USA. June 13–17, 2011. pp. 63-72. ASME. https://doi.org/10.1115/MSEC2011-50205
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