The aim of this study was to prepare a novel titanium-10tantalum-10niobium (Ti-Ta-Nb) alloy nanoscale coatings using sputter deposition and to evaluate their effect on osteoblast response. The three groups of Ti alloy used in this study were: (1) as-sputtered Ti-Ta-Nb coatings; (2) Ti-Ta-Nb disks; and (3) Ti6Al4V alloy disks as controls. The three surfaces were characterized using a x-ray diffractometer, a scanning electron microscope, a surface profilometer, and a contact angle measuring instrument. ATCC CRL 1486 human embryonic palatal mesenchymal cells were used to evaluate the cell responses. Cell attachment was measured using a coulter counter. After 4 days incubation, dsDNA, total protein, and alkaline phosphatase of the attached cells were assayed. The as-sputtered Ti-Ta-Nb coatings consisted of dense nanoscale grains. The Ti-Ta-Nb coatings exhibited significantly greater cell attachments compared to the two polished microgroove groups at 30minutes and 1hour. No significant differences were observed in dsDNA amount, total protein production and alkaline phosphatase specific activity among the three groups. These results demonstrated an equivalent performance for the Ti-Ta-Nb alloy and its nanoscale Ti-Ta-Nb coatings, suggesting an alternative biocompatible metal for use in dentistry and orthopedics.
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ASME 2006 International Manufacturing Science and Engineering Conference
October 8–11, 2006
Ypsilanti, Michigan, USA
Conference Sponsors:
- Manufacturing Engineering Division
ISBN:
0-7918-4762-4
PROCEEDINGS PAPER
Fabrication of a Nanoscale Ti-Ta-Nb Alloy Coating and Its Effect on Osteoblast Precursor Initial Response Available to Purchase
M. Appleford,
M. Appleford
University of Tennessee, Memphis, TN
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S. Park,
S. Park
Chonnam National University, Gwangju, South Korea
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Y. Kim,
Y. Kim
Chonnam National University, Gwangju, South Korea
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N. Choi,
N. Choi
Chonnam National University, Gwangju, South Korea
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D. J. Lee,
D. J. Lee
Chonnam National University, Gwangju, South Korea
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K. Lee,
K. Lee
Chonnam National University, Gwangju, South Korea
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J. Bumgardner,
J. Bumgardner
University of Memphis, Memphis, TN
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J. Ong
J. Ong
University of Tennessee, Memphis, TN
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Y. Yang
University of Tennessee, Memphis, TN
M. Moore
University of Tennessee, Memphis, TN
M. Appleford
University of Tennessee, Memphis, TN
Y. Liu
University of Tennessee, Memphis, TN
S. Kim
University of Tennessee, Memphis, TN
W. Chen
University of Tennessee, Memphis, TN
S. Oh
University of Tennessee, Memphis, TN
S. Park
Chonnam National University, Gwangju, South Korea
Y. Kim
Chonnam National University, Gwangju, South Korea
N. Choi
Chonnam National University, Gwangju, South Korea
D. J. Lee
Chonnam National University, Gwangju, South Korea
K. Lee
Chonnam National University, Gwangju, South Korea
J. Bumgardner
University of Memphis, Memphis, TN
W. Haggard
University of Memphis, Memphis, TN
J. Ong
University of Tennessee, Memphis, TN
Paper No:
MSEC2006-21044, pp. 355-361; 7 pages
Published Online:
October 2, 2008
Citation
Yang, Y, Moore, M, Appleford, M, Liu, Y, Kim, S, Chen, W, Oh, S, Park, S, Kim, Y, Choi, N, Lee, DJ, Lee, K, Bumgardner, J, Haggard, W, & Ong, J. "Fabrication of a Nanoscale Ti-Ta-Nb Alloy Coating and Its Effect on Osteoblast Precursor Initial Response." Proceedings of the ASME 2006 International Manufacturing Science and Engineering Conference. Manufacturing Science and Engineering, Parts A and B. Ypsilanti, Michigan, USA. October 8–11, 2006. pp. 355-361. ASME. https://doi.org/10.1115/MSEC2006-21044
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