Abstract
Organ-on-a-Chip (OoC) technology is an ever-evolving field that combines engineering and biological sciences. These offer advantages such as reduced sample consumption, faster and cheaper analysis, and improved microenvironment control. For these reasons, researchers have increasingly used OoCs platforms to deepen the understanding of disease mechanisms. However, ensuring accurate temperature control within these systems has been a challenge, and this is a critical factor influencing cellular behavior and experimental outcomes. For this reason, the integration of heating elements directly into the OoC devices has been explored.
The aim of the present work is to study the heat transfer from a generating element positioned at the bottom of the device and the fluid flow behavior within the OoC. To this end, computational fluid dynamics (CFD) simulations were performed using Ansys Fluent software. The findings indicate that the flow is laminar, and the temperatures obtained in the organoid allow to reproduce hyperthermia conditions.
