Mass transfer is a ubiquitous transfer phenomenon, efficient means of mass flux regulation are of great significance to various fields. Recently, because of superior physical properties, meta-materials have been widely concerned, and the research on flux regulation using meta-materials has been rapidly developed. However, the relevant research in the field of mass transfer has progressed much more slowly than expected. In this work, the characteristic regulation of gas diffusion in meta-material functional region was investigated. Through coordinate transformation, Fick diffusion equation and gas diffusivity were derived mathematically. Different kinds of homogeneous isotropic materials are alternately compounded based on equivalent medium theory to form meta-material functional region, which realize the characteristic regulation of oxygen, nitrogen and their mixtures. In addition, the simulation results are in agreement with the derived formulas mutually verified and quantitative analysis of geometric factors affecting gas regulation process is carried out.