The manipulation of micro- or nano-structure is a promising method to improve pool boiling heat transfer performance. However, most studies just focus on the micro- or nano-structure without considering the combination micro- and nano-structure. In this paper, we fabricated synergistic microchannel, nano-structure, and micro-nano structure surface on the nickel by different technologies. Pool boiling of DI water under saturated condition was experimentally investigated. Result shows at the wall superheat of 18 K, the heat transfer coefficient of micro-nano structure, nano-structure and synergistic micro-channel surface are 16400, 13050, and 13400 W/m2 K higher 89%, 50%, and 54% than that of smooth surface, respectively. The improved heat transfer is attributed to active nucleation sites and capillary flow.