Target drug delivery is one of the core issues in modern medicine. Although both thermo-sensitive and magnetic drug vehicles have been developed for this purpose, reliable drug targeting is yet to achieve, because it’s hard to control local temperature in body for thermo-sensitive drugs, and it’s also difficult to control the colloidal sizes of magnetic vehicles to meet the requirements for both long-time circulation and magnetic responsibility. Here we present a new technology to solve these two problems. The drug (taxel) was combined with hyper-branched thermo-sensitive polymer and magnetic nanoparticles. Magnetic responsibility of the complex can be remotely controlled by applying an alternating magnetic field. The untreated complexes were stable in dispersion, while after exposing to the alternating magnetic filed for 5 minutes, the complexes were destabilized and deposited from dispersion quickly. Unlike the commonly used water bath, the technology present here can heat up the drug vehicles remotely from outside, which must have great potentials in the applications of magnetic or thermo-sensitive drug delivery.
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ASME 2009 Second International Conference on Micro/Nanoscale Heat and Mass Transfer
December 18–21, 2009
Shanghai, China
Conference Sponsors:
- Nanotechnology Institute
ISBN:
978-0-7918-4391-8
PROCEEDINGS PAPER
A Novel Remote Controllable Drug Delivery System Triggered by Heating From Magnetic Nanoparticles
Xiaoliang Wang,
Xiaoliang Wang
Shanghai Jiao Tong University, Shanghai, China
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Hongchen Gu,
Hongchen Gu
Shanghai Jiao Tong University, Shanghai, China
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Xinyuan Zhu
Xinyuan Zhu
Shanghai Jiao Tong University, Shanghai, China
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Xiaoliang Wang
Shanghai Jiao Tong University, Shanghai, China
Hongchen Gu
Shanghai Jiao Tong University, Shanghai, China
Xinyuan Zhu
Shanghai Jiao Tong University, Shanghai, China
Paper No:
MNHMT2009-18052, pp. 449-452; 4 pages
Published Online:
October 26, 2010
Citation
Wang, X, Gu, H, & Zhu, X. "A Novel Remote Controllable Drug Delivery System Triggered by Heating From Magnetic Nanoparticles." Proceedings of the ASME 2009 Second International Conference on Micro/Nanoscale Heat and Mass Transfer. ASME 2009 Second International Conference on Micro/Nanoscale Heat and Mass Transfer, Volume 3. Shanghai, China. December 18–21, 2009. pp. 449-452. ASME. https://doi.org/10.1115/MNHMT2009-18052
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