This paper presents various designs of a handheld reader for an interferometric intraocular pressure measurement system. Reflected lights from the implanted sensor form interference fringes which can be captured using a camera. Image processing software was used to analyze the fringe pattern and determine the eye pressure. Various light sources were considered and the LED with a laser line filter was selected for its ability to generate quality fringe patterns and portability. Three generations of handheld readers have been developed and tested. Interference patterns acquired from each reader were compared to assess the limiting and promising features related to measurement time, form factor, working distance, ease of use, and quality of fringes. Results show that the DSLR-based reader has the highest quality images with the largest form factor while the smartphone-based reader offers the smallest form factor with ease of use and accessibility for the patient.