A holographic data storage system (HDSS) is very important field in the storage system device. Many researchers study the HDSS about image processing algorithm for reduction of image noise. In this work, we proposed an intelligence virtual mask, parameter values of virtual image mask generated using DNA coding method, it is available to decrease the IPI noise in HDSS. In this paper, an intensity distribution of laser beam in our HDSS is controlled by the virtual mask with an intelligence algorithm. The virtual mask value is changed arbitrarily in real-time with suggested DNA coding method in the HDSS.

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