Structural reliability is an engineering method that focuses on the calculation and prediction of the probability of failure for a structural system. Structural reliability is used by many pipeline operators to assess the probability of failure, and these probability of failure estimates are then used to manage safety, environmental, and operational risks for threats such as corrosion, cracking, and third-party damage. In the structural reliability approach, the probability of failure is obtained from a multi-dimensional integral, for which the solution is commonly estimated numerically using Direct Monte Carlo (DMC) simulation. DMC is straight-forward and robust but requires a significant amount of computational effort to estimate small probabilities, which are typical of threats to pipeline integrity. Subset Simulation is an approach that improves on the efficiency issues of DMC by representing the rare event probability as the product of a number of more frequent events, which are each estimated separately. Previous work published at IPC in 2020 by Bandstra and Fraser  showed very close agreement between DMC and Subset Simulation for a single defect reference case with a single limit state. This study extends that initial work by applying Subset Simulation to various failure models for a variety of pipeline defects. Subset Simulation is applied to the CSA corrosion model, PRCI MAT-8 crack model, and the EPRG dent failure model, and the performance is evaluated by comparing the results to DMC. For each of these comparisons, simulations are performed across a large-scale grid of validation cases that consider a range of pipeline and defect sizes. An approach that utilizes Subset Simulation to handle multiple limit states is also presented and applied for relevant failure models and the results are evaluated against DMC.