Boiling heat transfer from a 50-μm-diameter wire immersed in FC-72 is examined. Effects of pressure, subcooling, and dissolved gas concentration on nucleate boiling heat transfer and critical heat flux (CHF) are investigated. The current study is an ongoing effort to systematically quantify dissolved gas content effects on boiling heat transfer. The present investigators previously determined that gas-saturated boiling efficiency is affected by local degassing of the working fluid near the heater surface. This local degassing effect is further investigated in the present study using helium, air, and carbon dioxide as dissolved gases. In addition, the limits of gas-saturated boiling enhancement are determined by varying system pressure.