Velocity and wall shear stress patterns were studied in a model end-to-side anastomosis consisting of two equal diameter tubes joined at 45°. Photochromic dye tracer experiments and finite element-based numerical simulations were carried out under steady flow conditions at various Reynolds numbers. For ReD = 550, detailed mesh convergence studies were done. Good general agreement between computed and experimental velocity fields was seen, particularly in the presence of multiple complex separation zones. Good qualitative agreement in wall shear stresses was also seen, although quantitative agreement was less satisfactory, particularly within regions of complex separation. Computed wall shear stresses showed minor mesh dependence even when the velocity field appeared to be essentially “mesh-independent”, but were sufficiently accurate for purposes of hemodynamic studies. However, we caution that mesh-independence of velocities does not necessarily imply mesh-independence in the wall shear stress field.