The coupling of computational hemodynamics to endovascular diagnostics in human coronary artery stenoses during angioplasty procedures was evaluated. Calculated mean pressure gradients were much lower for physiologic flow than measured mean pressure gradients. The narrower flow cross-section with the catheter present effectively introduced a tighter stenosis than the enlarged residual stenoses after balloon angioplasty; thus elevating the pressure gradient and reducing blood flow during the measurements.

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