Abstract

A mechanistic model of arterial thrombosis has been developed, based on platelet transport by convection and shear-enhanced diffusion, and platelet adhesion at a lumped kinetic rate. The model is compared to platelet deposition on collagen-coated stenoses in an ex vivo thrombosis experiment that uses non-anticoagulated blood. In the converging regions of the stenosis, the model reproduces the spatial platelet deposition pattern, and matches deposition rates reasonably well. The model suggests that platelet thrombosis on type I collagen in stenotic arterial flow is transport-dominated.

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