Abstract

Rolling of the cell under flow conditions is an important process in PMN emigration. It is a finely regulated process involving membrane receptors and cell-matrix recognition. Several models have been proposed to explain how the strength and lifetime of the bonds in receptor-mediated cell-substratum are related to cell rolling velocity (Hammer, 1992, Tozeren, 1992, Zhao, 1995). The paper presents a simple model of the cell rolling based on the experimental measurements that will allow to gain information relevant to the molecular processes underlying the rolling motion of the cell.

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