In this paper, the effects of inlet turbulence on the development of turbulent flow and heat transfer in the entrance region of a helically coiled pipe are investigated by means of a fully elliptic numerical study. The k-ε standard two-equation turbulence model is used to simulate the three-dimensional turbulent flow and heat transfer. The governing equations are solved by a Control-Volume Finite Element Method with an unstructured nonuniform grid system. Numerical results presented in this paper cover a Prandtl number range of 0.02–100, and an inlet turbulence intensity range of 2–40 percent. The development of velocity field, temperature field, bulk turbulent kinetic energy, average friction factor, and average Nusselt number are discussed. It is found that bulk turbulent kinetic energy far from the entrance is not affected by the inlet turbulence level. Significant effects of the inlet turbulence level on the development of the friction factor and Nusselt number occur within a short axial distance from the entrance only.