Abstract
Organs-on-a-chip, OoC, have been extremely important to reduce the use of animal models allowing researchers to conduct accurate in vitro experiments with high throughput. Year after year, increasingly complex OoC platforms have been developed to better recapitulate the in vivo environment, and numerical simulations have played a fundamental role in this process. Numerical simulations in health sciences research are constantly evolving and have allowed researchers not only to better understand but also to complement and improve the in vitro experiments.
Aiming to evaluate the influence of geometry on fluid flow, in the present work, three different geometries of a single organ-on-a-chip were created, and numerical simulations were conducted by using Ansys® Fluent software. The fluid flow of the culture medium with dissolved oxygen was simulated. In terms of oxygen consumption, the influence of the geometry was noticeable in the organoid region. In terms of velocity fields, the results were not significantly affected by the geometry.
