The multi-temperature zone distributed drying method solves the problem of uneven drying of the conventional belt dryer. Multi-temperature zone belt dryer is widely used in the drying of aquatic feed products. This paper presents a numerical simulation method for multi-temperature zone belt dryer. The computational fluid dynamics (CFD) was applied to simulate the drying process of materials in a multi-temperature zone belt dryer. The user-defined function (UDF) was used to study the moisture-heat coupling drying process to predict the airflow filed of the multi-temperature zone belt dryer. The results showed that there were vortexes in each drying chamber so that airflow velocity distribution of the material layer was not uniform. However, the multi-temperature zone distributed drying method can maximize the drying efficiency through the bilateral distribution of the air inlet. The temperature distribution in each temperature zone was relatively uniform, and the temperature difference between the two sides of the feed layer was massive. The moisture content of the materials in each temperature zone was very uniform, the drying unevenness was less than 1.0%, and the dryer has excellent moisture content uniformity.