This paper presents a comparison of low- and high-fidelity structural analyses of a 10 MW offshore floating wind turbine rotor blade. For low-fidelity analysis, BeamDyn as a part of the OpenFAST toolset is used. For high-fidelity analysis, the Toolkit for the Analysis of Composite Structures (TACS) finite element method is used. First, several numerical examples with reference solutions from the literature are investigated to compare the accuracy and efficiency of the low- and high-fidelity structural models. Next, the DTU 10 MW reference wind turbine blade is analyzed using both the low- and high-fidelity methods. The bending response of the blade is analyzed. The results show that the high-fidelity model agrees with low-fidelity results and reference solutions. The high-fidelity model represents the deformations more accurately than the low-fidelity model and therefore is appropriate for structural analysis of complex wind turbine blade shapes.