Fentanyl, a synthetic opioid, is an extremely fast-acting synthetic narcotic analgesic having a high potency of approximately 100 to 200 times that of Morphine. As the synthetic opioid crisis continues to sweep across the world, detection technologies are required to be enhanced to detect, categorize, and identify synthetic opioids effectively. To detect fentanyl and its analogues, immunoassay screens are commercially available for urine specimens. Simple colorimetric assays, i.e., spot tests with paper strips, offer speed, simplicity of operation, portability, and affordability. The microfluidic behavior of the paper strips along with the properties of chemical reagents play significant role in drug detection methods. Therefore, the objectives of this study are to characterize the chemical properties of fentanyl and its analogues and to conduct microfluidic analysis for design optimization and performance evaluation of the fentanyl test strips. A computational fluid dynamics model is developed to evaluate the microfluidic properties. Analytical study and Experiments with test-kit samples are also conducted to validate the results of the numerical simulation. Finally, the performance parameters based on microfluidic analysis were reported showing the room for improvements in the detection technology of fentanyl and related synthetic opioids.

This content is only available via PDF.
You do not currently have access to this content.