Coronary artery ectasia is designated as abnormal focal dilatation of segments of the coronary artery and less frequently or diffuse dilatation along the entire coronary artery. In this study, we describe an image processing pipeline for automatic segmentation and centerline characterization from conventional X-ray angiography images. Two patients presenting with acute coronary syndrome and coronary artery ectasia are examined. Fluoroscopic views showing left and right coronary arteries were automatically quantified for vascular centerlines and arterial centerlines are rendered color-coded plots of regional vascular radius, to objectively characterize patient-specific regional vascular dilatation. Ectasia was found to be most pronounced in the proximal and mid-coronary segments and occurred preferentially in the areas of high curvature of the coronaries, along their course over the epicardial surface of the heart.

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