Energy consumption and thermal management have become key challenges in the design of large-scale data centers, where perforated tiles are used together with cold and hot aisles configuration to improve thermal management. Although full-field simulations using computational fluid dynamics and heat transfer (CFD/HT) tools can be applied to predict the flow and temperature fields inside data centers, their running time remains the biggest challenge to most modelers. In this paper, response surface methodology based on radial basis function is used to drastically reduce the running time while preserving the accuracy of the model. Response surface method with data interpolation allows the study of many design parameters of data center model more feasible and economical in terms of modeling time. Three scenarios of response surface construction are investigated (5%, 10%, and 20%). The method shows very good agreement with the simulation results obtained from CFD/HT model as in the case of 20% of the original CFD data points used for response surface training. Error analysis is carried out to quantify the error associated with each scenario. Case 20% shows superb accuracy as compared to others. With only 2.12 × 104 in mean relative error and R2 = 0.970, the case can capture most of the aspects of the original CFD model.

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