Biomanufacturing research involving solid freeform fabrication techniques has become fairly widespread in recent times. The layer-by-layer building concept provides an opportunity towards the development of a modular 3D printer to broaden the scope of biomanufacturing research. This research discusses the features of a Custom Multi-Modality 3D Bioprinter (CMMB) developed in the MARS lab at the University of Texas at Arlington (http://mars.uta.edu/). The CMMB currently includes a number of printing modules; two Fused Filament Fabrication (FFF), one Photo Polymerization (PP), one Viscous Extrusion (VE) and one Inkjet (IJ). The development of the custom bioprinter and each module are discussed; focusing on the advantages of a modular design, and on the unique features present in each individual module. Select constructs fabricated using individual or a combination of modules are presented and discussed. Design of Experiments (DOE) principles employing statistical software were used to characterize the CMMB; interactions between fabrication process parameters and their effect on deposited strand characteristics were analyzed. These results were employed to improve the quality of subsequently fabricated constructs. Initial experiments and fabricated constructs demonstrate that the custom bioprinter is a novel CAD-CAM biomanufacturing platform for research in methodologies, materials and processes for the fabrication of biomedical devices.

This content is only available via PDF.
You do not currently have access to this content.