The main driving mechanism during an asthmatic attack is the hyperconstriction of airway smooth muscle (ASM), which reduces the airway lumen and makes normal breathing difficult. The contraction can be relieved using bronchodilator drugs such as Isoproterenol, which induce temporary relaxation of the constricted airways. Pharmacological treatments are widely used in asthma, but their effectiveness varies from one subject to another, as do their side effects. Studies have shown that mechanical oscillations equivalent to physiological patterns such as breathing and deep inspiration in healthy airways can induce airway relaxation, but this type of response is not observed in asthmatics. Length oscillations seem to be a non-medicinal approach to treat ASM hyperconstriction present in many respiratory diseases such as asthma. Currently little is known about the effect of other oscillations’ patterns and their combination with breathing and deep inspiration on healthy and asthmatic airways during an asthmatic attack. Preliminary results obtained from in vitro and in vivo experiments in our laboratory indicate that the use of super imposed length oscillations (SILO) over normal breathing patterns can induce relaxation during an induced asthmatic attack on healthy and asthmatic subjects. These tests have been carried out using animal models which have been prepared under an acute protocol for the disease (new asthmatics), but these oscillations still remain to be tested in chronic asthmatic models (chronic asthmatics).

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