Molecular dynamics simulations are performed to provide valuable information about the translocation of four single-stranded DNAs with ten identical bases through graphene nanopore with diameter of 2 nm. The monolayer graphene nanopore is highly sensitive to ssDNA translocation events and the 10-base resolution detection can be realized by electrophoreticly threading ssDNA through graphene nanopore. Due to the similar sizes of the four nucleotides, the blockage current is unlikely to provide a distinguishable signal. However, by simply monitoring and analyzing the translocation time of poly(dA)10, poly(dC)10, poly(dG)10 and poly(dT)10 though graphene pore, each ssDNA can be identified and characterized.
The Molecular Dynamics Study for Detection of ssDNA by Monolayer Graphene Nanopore
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Si, W, Sha, J, Liu, L, Zhang, Y, & Chen, Y. "The Molecular Dynamics Study for Detection of ssDNA by Monolayer Graphene Nanopore." Proceedings of the ASME 2013 International Mechanical Engineering Congress and Exposition. Volume 3A: Biomedical and Biotechnology Engineering. San Diego, California, USA. November 15–21, 2013. V03AT03A046. ASME. https://doi.org/10.1115/IMECE2013-62384
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