A biosensor is an electronic device that measures biologically important parameters. An example is a sensor that measures the chemicals and materials released during corrosion of a biodegradable magnesium implant that impact surrounding cells, tissues and organs. A responsive biosensor is a biosensor that responds to its own measurements. An example is a sensor that measures the corrosion of an implant and automatically adjusts (slows down or speeds up) the corrosion rate. The University of Cincinnati, the University of Pittsburgh, North Carolina A&T State University, and the Hannover Medical Institute are collaborators in an NSF Engineering Research Center (ERC) for Revolutionizing Metallic Biomaterials (RBM). The center will use responsive sensors in experimental test beds to develop biodegradable magnesium implants. Our goal is to develop biodegradable implants that combine novel bioengineered materials based on magnesium alloys, miniature sensor devices that monitor and control the corrosion, and coatings that slow corrosion and release biological factors and drugs that will promote healing in surrounding tissues. Responsive biosensors will monitor what is happening at the interface between the implant and tissue to ensure that the implant is effective, biosafe, and provides appropriate strength while degrading. Corrosion behavior is a critical factor in the design of the implant. The corrosion behavior of implants will be studied using biosensors and through mathematical modeling. Design guidelines will be developed to predict the degradation rate of implants, and to predict and further study toxicity arising from corrosion products (i.e., Mg ion concentrations, pH levels, and hydrogen gas evolution). Knowing the corrosion rate will allow estimations to be made of implant strength and toxicity risk throughout the degradation process.
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ASME 2009 International Mechanical Engineering Congress and Exposition
November 13–19, 2009
Lake Buena Vista, Florida, USA
Conference Sponsors:
- ASME
ISBN:
978-0-7918-4387-1
PROCEEDINGS PAPER
Responsive Biosensors for Biodegradable Magnesium Implants Available to Purchase
Mark J. Schulz,
Mark J. Schulz
University of Cincinnati, Cincinnati, OH
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Amos Doepke,
Amos Doepke
University of Cincinnati, Cincinnati, OH
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Xuefei Guo,
Xuefei Guo
University of Cincinnati, Cincinnati, OH
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Julia Kuhlmann,
Julia Kuhlmann
University of Cincinnati, Cincinnati, OH
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Brian Halsall,
Brian Halsall
University of Cincinnati, Cincinnati, OH
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William Heineman,
William Heineman
University of Cincinnati, Cincinnati, OH
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Zhongyun Dong,
Zhongyun Dong
University of Cincinnati, Cincinnati, OH
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Zongqin Tan,
Zongqin Tan
University of Cincinnati, Cincinnati, OH
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Dingchuan Xue,
Dingchuan Xue
University of Cincinnati, Cincinnati, OH
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Namheon Lee,
Namheon Lee
University of Cincinnati, Cincinnati, OH
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Yeoheung Yun,
Yeoheung Yun
University of Cincinnati, Cincinnati, OH
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Yijun Liu,
Yijun Liu
University of Cincinnati, Cincinnati, OH
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Douglas Hurd,
Douglas Hurd
University of Cincinnati, Cincinnati, OH
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Vesselin Shanov,
Vesselin Shanov
University of Cincinnati, Cincinnati, OH
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Durgesh Rai,
Durgesh Rai
University of Cincinnati, Cincinnati, OH
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Frank Witte,
Frank Witte
Hannover Medical School, Hannover, Germany
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Dhananjay Kumar,
Dhananjay Kumar
North Carolina A&T State University, Greensboro, NC
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Sergey Yarmolenko,
Sergey Yarmolenko
North Carolina A&T State University, Greensboro, NC
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Sarah K. Pixley,
Sarah K. Pixley
University of Cincinnati, Cincinnati, OH
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Tracy Hopkins,
Tracy Hopkins
University of Cincinnati, Cincinnati, OH
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Chaminda Jayasinghe,
Chaminda Jayasinghe
University of Cincinnati, Cincinnati, OH
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Surya Sundaramurthy
Surya Sundaramurthy
University of Cincinnati, Cincinnati, OH
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Mark J. Schulz
University of Cincinnati, Cincinnati, OH
Amos Doepke
University of Cincinnati, Cincinnati, OH
Xuefei Guo
University of Cincinnati, Cincinnati, OH
Julia Kuhlmann
University of Cincinnati, Cincinnati, OH
Brian Halsall
University of Cincinnati, Cincinnati, OH
William Heineman
University of Cincinnati, Cincinnati, OH
Zhongyun Dong
University of Cincinnati, Cincinnati, OH
Zongqin Tan
University of Cincinnati, Cincinnati, OH
Dingchuan Xue
University of Cincinnati, Cincinnati, OH
Namheon Lee
University of Cincinnati, Cincinnati, OH
Yeoheung Yun
University of Cincinnati, Cincinnati, OH
Yijun Liu
University of Cincinnati, Cincinnati, OH
Douglas Hurd
University of Cincinnati, Cincinnati, OH
Vesselin Shanov
University of Cincinnati, Cincinnati, OH
Durgesh Rai
University of Cincinnati, Cincinnati, OH
Frank Witte
Hannover Medical School, Hannover, Germany
Dhananjay Kumar
North Carolina A&T State University, Greensboro, NC
Sergey Yarmolenko
North Carolina A&T State University, Greensboro, NC
Sarah K. Pixley
University of Cincinnati, Cincinnati, OH
Tracy Hopkins
University of Cincinnati, Cincinnati, OH
Chaminda Jayasinghe
University of Cincinnati, Cincinnati, OH
Surya Sundaramurthy
University of Cincinnati, Cincinnati, OH
Paper No:
IMECE2009-13101, pp. 109-116; 8 pages
Published Online:
July 8, 2010
Citation
Schulz, MJ, Doepke, A, Guo, X, Kuhlmann, J, Halsall, B, Heineman, W, Dong, Z, Tan, Z, Xue, D, Lee, N, Yun, Y, Liu, Y, Hurd, D, Shanov, V, Rai, D, Witte, F, Kumar, D, Yarmolenko, S, Pixley, SK, Hopkins, T, Jayasinghe, C, & Sundaramurthy, S. "Responsive Biosensors for Biodegradable Magnesium Implants." Proceedings of the ASME 2009 International Mechanical Engineering Congress and Exposition. Volume 14: Processing and Engineering Applications of Novel Materials. Lake Buena Vista, Florida, USA. November 13–19, 2009. pp. 109-116. ASME. https://doi.org/10.1115/IMECE2009-13101
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