In this work, we report a novel passive micromixer based on the perturbation of chaotic micro-bubbles. The sample flows (ink solution and water) were co-injected with nitrogen in a flow focusing orifice to generate side-by-side laminar flows segmented by monodisperse bubbles. The bubble flow subsequently enters a mixing chamber downstream, upon which the hydrodynamic interactions between two adjacent bubbles result in the stretching and folding of the laminar flow interface, which leads to a rapid chaotic mixing and complete homogenization of two separated streams. Our technique provides a simple, passive, and effective mixing mechanism for sample homogenization in microfluidic devices.

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