Atomistic simulation studies of dislocation nucleation and propagation in nanoscale multilayered metallic systems (Cu-Ni and Cu-Nb) are performed. Nanoindentation model is used to generate dislocations at and near the surface. Interaction of the propagating dislocations with two types of interfaces (coherent and incoherent) is analyzed. In the case of coherent interface, Cu(111)-Ni(111), dislocations that initiate in Cu layer propagate through the interface into Ni. However, the interface acts as an obstacle for dislocation propagation and leads to a higher dislocation density near the interface. In the case of incoherent interface, Cu(111)-Nb(110), dislocations that initiate in Cu do not propagate into Nb and tend to accumulate in copper near the interface. In both cases, the interfaces provide mechanisms for strengthening the nanoscale multilayered metallic systems.

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