Atherosclerotic plaque rupture and progression have been the focus of intensive investigations in recent years. The mechanisms governing plaque progression and rupture process are not well understood. Using computational models based on patient-specific multi-year in vivo MRI data, our recent results indicated that 18 out of 21 patients studied showed significant negative correlation between plaque progression measured by vessel wall thickness increase (WTI) and plaque wall (structural) stress (PWS) [1]. In this paper, a computational procedure based on meshless generalized finite difference (MGFD) method and serial magnetic resonance imaging (MRI) data was introduced to simulate plaque progression. Participating patients were scanned three times (T1, T2, and T3, at intervals of approximately 18 months) to obtain plaque progression data. Vessel wall thickness (WT) changes were used as the measure for plaque progression. Starting from T2 plaque geometry, plaque progression was simulated by solving the solid model and adjusting wall thickness using plaque growth functions iteratively until time T3 is reached. Numerically simulated plaque progression showed very good agreement with actual plaque geometry at T3 given by MRI data. We believe this is the first time plaque progression simulation results based on multi-year patient-tracking data are reported. Multi-year tracking data and MRI-based progression simulation add time dimension to plaque vulnerability assessment and will improve prediction accuracy.
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ASME 2008 International Mechanical Engineering Congress and Exposition
October 31–November 6, 2008
Boston, Massachusetts, USA
Conference Sponsors:
- ASME
ISBN:
978-0-7918-4863-0
PROCEEDINGS PAPER
Human Carotid Atherosclerotic Plaque Growth Function and Progression Simulation Using Meshless GFD and Statistical Methods Based on Multi-Year In Vivo MRI Available to Purchase
Chun Yang,
Chun Yang
Beijing Normal University, Beijing, China
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Joseph D. Petruccelli,
Joseph D. Petruccelli
Worcester Polytechnic Institute, Worcester, MA
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Zhongzhao Teng,
Zhongzhao Teng
Worcester Polytechnic Institute, Worcester, MA
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Chun Yuan,
Chun Yuan
University of Washington, Seattle, WA
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Gador Canton,
Gador Canton
University of Washington, Seattle, WA
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Thomas S. Hatsukami,
Thomas S. Hatsukami
University of Washington, Seattle, WA
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Dalin Tang
Dalin Tang
Worcester Polytechnic Institute, Worcester, MA
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Chun Yang
Beijing Normal University, Beijing, China
Joseph D. Petruccelli
Worcester Polytechnic Institute, Worcester, MA
Zhongzhao Teng
Worcester Polytechnic Institute, Worcester, MA
Chun Yuan
University of Washington, Seattle, WA
Gador Canton
University of Washington, Seattle, WA
Fei Liu
University of Washington, Seattle, WA
Thomas S. Hatsukami
University of Washington, Seattle, WA
Dalin Tang
Worcester Polytechnic Institute, Worcester, MA
Paper No:
IMECE2008-66759, pp. 93-94; 2 pages
Published Online:
August 26, 2009
Citation
Yang, C, Petruccelli, JD, Teng, Z, Yuan, C, Canton, G, Liu, F, Hatsukami, TS, & Tang, D. "Human Carotid Atherosclerotic Plaque Growth Function and Progression Simulation Using Meshless GFD and Statistical Methods Based on Multi-Year In Vivo MRI." Proceedings of the ASME 2008 International Mechanical Engineering Congress and Exposition. Volume 2: Biomedical and Biotechnology Engineering. Boston, Massachusetts, USA. October 31–November 6, 2008. pp. 93-94. ASME. https://doi.org/10.1115/IMECE2008-66759
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