MRI guided focused ultrasound (FUS) has been shown to create thermal lesions where tissue stiffness changes significantly. To assess the correlation between tissue stiffness change and tissue ablation, a pilot animal based study was conducted to treat LNCaP tumors in vivo and Hep3B tumors immediately post mortem. MR elastography was used to analyze tissue stiffness before and after ablation. Treated tissue was excised immediately after each experiment and processed by routine histological analysis. Four prostate cancer tumors and four liver cancer tumors showed, on average, a threefold increase in stiffness due to FUS thermal treatment. Histology showed complete (100%) coagulation necrosis in these cases. These data suggest that MRE may be an effective means to assess tissue ablation.

Volume Subject Area:
Bioengineering
Topics:
Cancer, Elastography, Magnetic resonance, Surgery, Ultrasound, Biological tissues, Stiffness, Tumors, Ablation (Vaporization technology), Liver, Magnetic resonance imaging
1.
Wu
F.
,
Wang
Z. B.
,
Cao
Y. D.
,
Chen
W. Z.
,
Bai
J.
,
Zou
J. Z.
,
Zhu
H.
,
2003
, “
A randomized clinical trial of high-intensity focused ultrasound ablation for the treatment of patients with localised breast cancer
,”
British Journal of Cancer
, Vol.
89
, pp.
2227
–
2233
.
2.
Gianfelice
D.
,
Khiat
A.
,
Amara
M.
,
Belblidia
A.
,
Boulanger
Y.
,
2003
, “
MR imaging-guided focused ultrasound surgery of breast cancer: correlation of dynamic contrast-enhanced MRI with histopathologic findings
,”
Breast Cancer Research and Treatment
, Vol.
82
, pp.
93
–
101
.
3.
Sarvazyan
A. P.
,
Rudenko
O. V.
,
Swanson
S. D.
,
Fowlkes
J. B.
,
Emelianov
S. Y.
,
1998
, “
Shear wave elasticity imaging: a new ultrasonic technology of medical diagnostics
,”
Ultrasound in Medicine & Biology
, Vol.
24
, pp.
1419
–
1435
.
4.
Wu
T.
,
Felmlee
J. P.
,
Greenleaf
J. F.
,
Riederer
S. J.
,
Ehman
R. L
,
2001
, “
Assessment of thermal tissue ablation with MR Elastography
,”
Magnetic Resonance in Medicine
, Vol.
45
, pp.
80
–
87
.
5.
Le
Y
,
Glaser
K
,
Rouviere
O.
,
Ehman
R. L
,
Felmlee
JP.
,
2006
, “
Feasibility of simultaneous temperature and tissue stiffness detection by MRE
,”
Magnetic Resonance in Medicine
, Vol.
55
, pp.
700
–
705
6.
Muthupillai
R.
,
Rossman
P. J.
,
Greenleaf
J. F.
,
Riederer
S. J.
,
Ehman
R. L.
,
1995
, “
Magnetic Resonance elastography by direct visualization of propagating acoustic strain waves
,”
Science
, Vol.
269
, pp.
1854
–
1857
.
7.
Manduca
A.
,
Oliphant
T. E.
,
Dresner
M. A.
,
Mahowald
J. L.
,
Kruse
S. A.
,
Amromin
E.
,
Felmlee
J. P.
,
Greenleaf
J. F.
,
Ehman
R. L.
,
2001
, “
Magnetic resonance elastography: non-invasive mapping of tissue elasticity
,”
Medical Image Analysis
, Vol.
5
, pp.
237
–
254
.
8.
Chan, Q.C.C., Li, G., Ehman, R.L., Grimm, R.C., Cao, G., Li, R., Yang, E. S., “Localized Application of Shear waves to Tissue for MR Elastography Via a Needle Device,” Program ISMRM 2005, 2010.
9.
Yin, M., Manduca, A., Harris, P.C., Torres, V.E., Ehman, R.L., 2006, “MR Elastography of the liver in an animal model of hepatic fibrosis”, ISMRM 2006, 39
This content is only available via PDF.
Copyright © 2006
 by ASME
You do not currently have access to this content.